Sr Director, GMASE Portfolio Execution- RIRU

Business Introduction

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.

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Our approach to R&D

Position Summary

The purpose of the Global Monitoring & Site Engagement – Sr Director of Portfolio Execution – (RIRU) is to serve as the single accountable leader for therapeutic area execution within GMASE, translating R&D and therapeutic strategy into predictable, high-quality clinical delivery at scale.

Operating within the DevOps model, this role owns GMASE’s execution outcomes for the therapeutic area, ensuring that clinical delivery moves from fragmented, study-by-study execution to a consistent, data-driven, and continuously connected delivery system across programs, countries, and partners. The position is accountable for how GMASE plans, deploys, and optimizes resources, site engagement, monitoring approaches, and risk management to deliver the therapeutic area portfolio, not for setting GSK therapeutic strategy or scientific direction.

In close partnership with Disease Area Leaders (DALs), therapeutic area leadership, and DevOps counterparts, the position serves as GMASE’s execution lead, converting strategic intent into measurable improvements across GMASE’s value drivers — velocity, quality, predictability, expertise, and productivity. Through leadership of Global Program Leads and close coordination with Planning & Strategic Feasibility, GCSD, DS&M, Clinical Science, Regulatory, and external CRO partners, this position puts the DevOps operating model into practice within GMASE, positioning GMASE as the engine of continuous, AI-enabled evidence generation for the therapeutic area.

Key Responsibilities

• Own therapeutic area execution for GMASE as a continuous, AI-enabled evidence generation engine, with full accountability for how the TA portfolio is delivered across programs, studies, countries, and partners in alignment with DevOps principles.

• Provide GMASE’s execution and delivery-feasibility input into Disease Area Strategy Plans, acting as GMASE’s senior execution counterpart to Disease Area Leaders (DALs) and TA stakeholders, representing GMASE in TA-level execution discussions, trade-offs, and delivery commitments, while partnering closely on priorities and outcomes.

• Establish GMASE TA-level execution alignment with Planning & Strategic Feasibility, ensuring portfolio priorities, commercial positioning, feasibility insights, and delivery strategies are coherently translated into executable, scalable plans.

• Own GMASE TA-level portfolio performance oversight, including setting expectations, reviewing execution signals and evidence assurance data, identifying systemic risks and constraints, and driving timely resolution through structured escalation and cross-functional decision-making.

• Provide senior leadership and talent stewardship for Global Program Leads (GPLs), including setting execution standards, strengthening decision quality, building leadership capability through fit-for-purpose onboarding and development, and holding accountability for performance; may include direct line management of GPLs.

• Ensure appropriate site engagement for the TA, building GMASE’s site network as durable infrastructure rather than a study-by-study relationship — defining with key stakeholders and overseeing GMASE TA-wide site engagement and relationship strategies, including site tiering aligned to enterprise priorities, focusing GMASE focuses effort where it most impacts velocity, quality, and predictability.

• Own GMASE’s execution governance for outsourced delivery within the TA, setting expectations with CRO partners, overseeing performance, and resolving delivery issues and escalations to ensure consistent, high-quality outcomes.

• Ensure GMASE effective cross-functional execution governance, connecting GPLs and study teams to the appropriate decision-makers across GCSD, DS&M, Clinical Science, Regulatory, and other partners to remove systemic barriers and prevent fragmented delivery.

• As a member of the GMASE Leadership Team, chair GMASE therapeutic area portfolio governance forums, including monthly TA reviews with Country Heads and functional partners, to drive performance transparency, resource alignment, and execution readiness, and contribute TA-level insight and recommendations to the Leadership Team.

• Maximize the use of AI-enabled tools and workflows across GMASE TA execution and monitoring to accelerate trial timelines, reduce trial costs, and reduce time spent on manual tasks, continuously optimizing resource deployment and monitoring approaches based on actual utilization and delivery needs.

Why You?

Basic Qualification

We are seeking professionals with the following required skills and qualifications to help us achieve our goals

• Bachelor’s degree in life sciences, healthcare, business or a related field, or equivalent experience.

• Minimum of 10 years of pharmaceutical R&D or related industry experience.

• Extensive (8+ years) leadership experience in clinical operations within the relevant therapeutic area.

• Deep therapeutic area expertise and understanding of Respiratory/Immunology strategy, data, operational needs, and commercial positioning to enable aligned execution.

• Experience owning end-to-end execution outcomes at portfolio or TA level, including accountability for delivery tradeoffs, risk resolution, and performance.

Preferred Qualification

If you have the following characteristics, it would be a plus

• Advanced degree (Master’s, PhD, PharmD, MD) in a relevant discipline.

• Experience with real-world evidence, health economics and outcomes research, or epidemiology.

• Demonstrated ability to lead cross-functional teams, resolve complex issues, and drive study and portfolio performance.

• Strong global stakeholder management experience across GCSD, DS&M, Clinical Science, Regulatory, and country organizations.

• Proven experience coaching and developing operational leaders.

• Day-to-day fluency in using AI to accelerate trial timelines, improve data quality, evidence assurance, and reduce time spent on manual tasks.

• Risk Based Quality Management knowledge.

• Experience leading global portfolios or cross-region evidence programs.

• Strong data fluency, including experience using dashboards and performance metrics to drive decisions.

• Experience with vendor oversight and partnerships with CROs, academic networks or external investigators.

• Demonstrated success delivering process improvements or digital-enabled transformation in evidence generation.

How to apply

If this role matches your experience and ambitions, please apply. We welcome candidates from all backgrounds who share our mission to get ahead of disease together. Tell us how your skills and experience will help deliver impact in this role.

Skills

Agile Thinking, Business Acumen, Clinical Development, Clinical Trial Designs, Communication, Creativity, Decision Making, Fostering Collaboration, Good Clinical Practice (GCP), Influencing Without Authority, People Management, Pharmaceutical Industry, Project Management, Study DesignThe US annual base salary for new hires in this position ranges from $189,750 to $316,250. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.Polish Salary Range / Polski przedział wynagrodzenia: PLN 509,250 to PLN 848,750The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate’s skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. More detailed information on the total benefits package will be supplied during the recruitment process. This role is available for applicants from multiple locations, and therefore salary ranges for certain locations are also shown. Salary ranges for other locations are shown because some markets have pay transparency laws that require salary information on job postings, and those locations are potential job sites for this role. If salary ranges are not displayed in the job posting for a specific location or country, the relevant compensation will be discussed during the recruitment process. Please note salaries vary by country based on the candidate’s skills, experience, education level and the market rate for the role. Offers are typically made within the advertised range based on the candidate’s skills, experience and qualifications, with the upper end generally reserved for highly experienced candidates or other exceptional circumstances aligned with these criteria.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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Originally posted on Himalayas