Principal Biostatistician/ Sr Biostatistician (R/Rshiny - EMEA BASED) - Pipeline

Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress.

Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.

Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.

Discover what your 25,000 future colleagues already know:

Why Syneos Health

• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
  • We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.
  • We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.

Job Responsibilities

Industry experience as a Biostatistician using R is required. Rshiny would be advantage

Role Summary

The Principal Biostatistician – will leverage interactive R applications to explore, analyze, and communicate insights from clinical trial data. This role combines clinical trial expertise, statistical thinking, and modern R programming to support exploratory analyses, facilitate scientific discussions, and generate actional insights for study teams.

The successful candidate will work closely with statisticians, clinicians, and R application developers to identify meaningful analytical questions, prepare clinical datasets, generate interactive visualizations, and drive improvements to the DIG analytical platform.

Key Responsibilities

• Perform exploratory analyses of clinical trial data using interactive R/Shiny applications.
  - Prepare, integrate, and quality-check clinical datasets for downstream exploratory analyses.
  - Identify trends, safety signals, efficacy patterns, subgroup differences, and data quality issues through interactive visualization.
  - Lead data review sessions and exploratory analysis meetings using interactive visualizations to communicate findings and facilitate scientific discussions.
  - Translate complex statistical results into clear visual narratives that support clinical decision making.
  - Collaborate with clinicians, statisticians, programmers, and R application developers to define analytical requirements and prioritize new application features.
  - Develop reproducible analytical workflows and reports using modern R tools.
  - Contribute enhancements, bug reports, and feature requests to continuously improve the application ecosystem.
  - Train and support users of internally developed analytical applications.
  - Stay current with emerging analytical methodologies and visualization techniques within the R ecosystem.

Minimum Qualifications

• Previous experience using R for statistical analysis and data visualization, including experience with Shiny applications.
  - MS or PhD in Biostatistics, Statistics, Mathematics, Data Science, or a related quantitative discipline, with experience supporting clinical development within the pharmaceutical, biotechnology, or CRO industry.
  - Strong understanding of clinical trial design, statistical methodology, and clinical data standards.
  - Excellent communication and presentation skills, with the ability to explain complex statistical concepts to multidisciplinary audiences.
  - Strong collaboration and stakeholder management skills.
  - Ability to thrive in a Dynamic Shared Ownership (DSO) environment.
  - Fluency in English

- Based in Europe

Technical Skills

Clinical Data & Statistics

• Strong understanding of SDTM and ADaM datasets.
  - Experience conducting exploratory analyses of efficacy and safety data.
  - Knowledge of statistical methodology used throughout clinical development.
  - Experience interpreting and communicating statistical findings.

R Programming

Demonstrated experience with:

- Advanced R programming

• Data manipulation and transformation
  - Reproducible analytical workflows
  - Experience with packages such as: shiny, plotly, ggplot2, dplyr, tidyr, purr, gt, gtsummary, reactable

Data Visualization

Experience creating and presenting interactive visualizations using shiny, plotly, ggplot2, and/or other visualization packages.
Ability to effectively communicate clinical findings through interactive graphics and dashboards

Reproducible Analysis

Experience with:

- Quarto or RMarkdown

- Git and GitHub

• Reproducible reporting
  - Quality control of analytical datasets

- Collaborative analytical workflows

Preferred Qualifications

Experience with one or more of:

- Posit Connect

• R package development
  - SQL
  - Arrow or DuckDB
  - AI-assisted analytical workflows
  - Machine learning methods for exploratory analyses
  - Clinical dashboards and interactive reporting
  - User training and scientific presentations
  - Familiarity with software development workflows and contributing feature requests to application development teams

Get to know Syneos Health

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.

No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.

Additional Information

Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.

Originally posted on Himalayas